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KMID : 0604519970230030115
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Journal of the Society of Cosmetic Scientists of Korea
1997 Volume.23 No. 3 p.115 ~ p.121
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The Effects of Whitening Components on Human Melanocytes in Vitro
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Cho, Joon Hwan
Kee, Ki Moo/Kim, Nam Soo/Kang, Won-Hyoung
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Abstract
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To indentify inhibitors of melanogenesis, we compared the effects of 5 compou nds(arbutin, ascorbic acid, azelaaic acid, kojic acid, and tranexamic acid) on mushroom tyrosinase, human melanocytic tyrosinase activity and melanin content The cytotomity of the components were also tested on cultured human melanocytes.
Kojic acid showed marked inhibitory effect both on mushroom and human tyrosinase activity. This action of kojic acid is stronger than that of ascorbic acid. Arbutin inhibited human tyrosinase activity of cultured melanocytes although it had slightly inhibitory effect on mushroom tyrosinase activity. Azelaic acid had no effect on human tyrosinase activity. Melanin production was inhibited significantly by kojic acid and tranexamic acid. MTT assay showed that all of the compounds were non-cytotoxic to melanocytes at the concentrations tested.
These results suggest that the effects of kojic acid out cultured melanocytes involve inhibition of tyrosinase activity and melanogenesis without affecting the cell number.
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